Iphakheji yeMveli ye-OEM yeMacrocephalae Rhizoma oyile yendalo

inkcazo emfutshane:

Njenge-arhente esebenzayo ye-chemotherapy, i-5-fluorouracil (5-FU) isetyenziswa kakhulu kunyango lwee-tumors ezinobungozi kwindlela yesisu, entloko, entanyeni, esifubeni, nakwi-ovary. Kwaye i-5-FU liyeza lokuqala lomhlaza we-colorectal kwiklinikhi. Indlela yokusebenza ye-5-FU kukuthintela ukuguqulwa kwe-uracil nucleic acid ibe yi-thymine nucleic acid kwiiseli ze-tumor, emva koko ichaphazele ukwenziwa kunye nokulungiswa kwe-DNA kunye ne-RNA ukuze kufezekiswe isiphumo sayo se-cytotoxic (Afzal et al., 2009; Ducreux et al., 2015; Longley et al., 2003). Nangona kunjalo, i-5-FU ikwavelisa isifo sohudo esibangelwa yi-chemotherapy (CID), esinye sezona ziphumo zixhaphakileyo ezichaphazela izigulane ezininzi (Filho et al., 2016). Ukuxhaphaka korhudo kwizigulana ezinyangwe nge-5-FU bekufikelele kwi-50%–80%, nto leyo eyachaphazela kakhulu inkqubela phambili kunye nokusebenza kakuhle kwe-chemotherapy (Iacovelli et al., 2014; Rosenoff et al., 2006). Ngenxa yoko, kubaluleke kakhulu ukufumana unyango olusebenzayo lwe-5-FU induced CID.

Okwangoku, iindlela zokungenelela ezingezizo iziyobisi kunye neendlela zokungenelela amayeza ziye zangeniswa kunyango lwezonyango lwe-CID. Iindlela zokungenelela ezingezizo iziyobisi ziquka ukutya okufanelekileyo, kunye nezongezo ezinetyuwa, iswekile kunye nezinye izondlo. Amayeza afana ne-loperamide kunye ne-octreotide asetyenziswa rhoqo kunyango lwe-CID yokulwa norhudo (Benson et al., 2004). Ukongeza, amayeza e-ethnomedicines nawo asetyenziswa ukunyanga i-CID ngonyango lwawo olulodwa kumazwe ahlukeneyo. Amayeza emveli aseTshayina (i-TCM) yenye yeendlela zonyango eziqhelekileyo eziye zenziwa iminyaka engaphezu kwama-2000 kumazwe aseMpuma Asia kuquka iTshayina, iJapan kunye neKorea (Qi et al., 2010). I-TCM ithi amayeza e-chemotherapeutic angabangela ukusetyenziswa kwe-Qi, ukungabikho kwe-spleen, ukuphazamiseka kwesisu kunye nokufuma kwe-endophytic, okubangela ukungasebenzi kakuhle kwamathumbu. Kwithiyori ye-TCM, icebo lokunyanga i-CID kufuneka lixhomekeke kakhulu ekongezeni i-Qi kunye nokuqinisa i-spleen (Wang et al., 1994).

Iingcambu ezomileyo zeI-Atractylodes macrocephalaKoidz. (AM) kunyeI-Panax ginsengI-CA Mey. (PG) ngamayeza aqhelekileyo emifuno kwi-TCM aneziphumo ezifanayo zokongeza i-Qi kunye nokuqinisa i-spleen (Li et al., 2014). I-AM kunye ne-PG zihlala zisetyenziswa njenge-herb pair (uhlobo olulula lokuhambelana kwemifuno yaseTshayina) kunye neziphumo zokongeza i-Qi kunye nokuqinisa i-spleen ukunyanga urhudo. Umzekelo, i-AM kunye ne-PG zibhalwe kwiifomyula zakudala zokulwa norhudo ezifana noShen Ling Bai Zhu San, uSi Jun Zi Tang ovela kwiTaiping Huimin Heji Ju Fang(Ubukhosi beNgoma, iChina) kunye noBu Zhong Yi Qi Tang ukusukaUPi Wei Lun(Ubukhosi bukaYuan, eTshayina) (Umzobo 1). Izifundo ezininzi zangaphambili zibike ukuba zonke ezi fomula zintathu zinamandla okunciphisa i-CID (Bai et al., 2017; Chen et al., 2019; Gou et al., 2016). Ukongeza, uphando lwethu lwangaphambili lubonise ukuba iShenzhu Capsule equlethe i-AM kunye ne-PG kuphela inefuthe elinokubakho kunyango lwesifo sohudo, i-colitis (xixie syndrome), kunye nezinye izifo zesisu (Feng et al., 2018). Nangona kunjalo, akukho phando luxoxe ngempembelelo kunye nendlela ye-AM kunye ne-PG ekunyangeni i-CID, nokuba kudibene okanye kukodwa.

Ngoku i-gut microbiota ithathwa njengeyona nto inokwenzeka ekuqondeni indlela yokunyanga ye-TCM (Feng et al., 2019). Izifundo zanamhlanje zibonisa ukuba i-gut microbiota idlala indima ebalulekileyo ekugcineni i-homeostasis yamathumbu. I-gut microbiota esempilweni inegalelo ekukhuselweni kwe-mucosal yamathumbu, imetabolism, i-immune homeostasis kunye nempendulo, kunye nokucinezelwa kwe-pathogen (Thursby and Juge, 2017; Pickard et al., 2017). I-gut microbiota ephazamisekileyo iphazamisa imisebenzi yomzimba kunye neyomzimba yomzimba womntu ngokuthe ngqo okanye ngokungathanga ngqo, ibangela iimpendulo ezingalindelekanga ezifana ne-diarrhea (Patel et al., 2016; Zhao and Shen, 2010). Uphando lubonise ukuba i-5-FU yatshintsha ngokuphawulekayo ulwakhiwo lwe-gut microbiota kwiimpuku ezirhudayo (Li et al., 2017). Ke ngoko, iziphumo ze-AM kunye ne-PM kwi-5-FU diarrhea zinokulawulwa yi-gut microbiota. Nangona kunjalo, ukuba i-AM kunye ne-PG zodwa kwaye xa zidibene zinokuthintela i-5-FU diarrhea ngokuguqula i-gut microbiota akukaziwa.

Ukuze siphande ngemiphumo yokulwa norhudo kunye nendlela esisiseko ye-AM kunye ne-PG, sisebenzise i-5-FU ukulinganisa imodeli yorhudo kwiimpuku. Apha, sigxile kwimiphumo enokubakho yolawulo olunye noludibeneyo (AP) lweI-Atractylodes macrocephalaioyile ebalulekileyo (AMO) kunyeI-Panax ginsengi-total saponins (PGS), izinto ezisebenzayo ezithathwe kwi-AM kunye ne-PG ngokulandelelana, kwisifo sorhudo, isifo samathumbu kunye nolwakhiwo lweentsholongwane emva kwe-5-FU chemotherapy.