OEM Custom Package Natural Macrocephalae ioli Rhizoma

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Njenge-agent ye-chemotherapeutic esebenzayo, i-5-fluorouracil (i-5-FU) isetyenziswe ngokubanzi kunyango lwe-tumor enobungozi kwi-gastrointestinal tract, intloko, intamo, isifuba kunye ne-ovary. Kwaye i-5-FU lichiza lokuqala lomhlaza womlomo ekliniki. Indlela yokusebenza ye-5-FU kukuthintela ukuguqulwa kwe-uracil nucleic acid kwi-thymine nucleic acid kwiiseli ze-tumor, emva koko ichaphazele ukuhlanganiswa kunye nokulungiswa kwe-DNA kunye ne-RNA ukufezekisa umphumo wayo we-cytotoxic (Afzal et al., 2009; Ducreux et. al., 2015; Longley et al., 2003). Nangona kunjalo, i-5-FU iphinda ivelise i-chemotherapy-induced diarrhea (CID), enye yezona zinto zixhaphakileyo ezichaphazela izigulane ezininzi (Filho et al., 2016). Iziganeko zesifo sohudo kwizigulane eziphathwe nge-5-FU zafikelela kwi-50% -80%, eyachaphazela kakhulu inkqubela kunye nokusebenza kwe-chemotherapy (Iacovelli et al., 2014; Rosenoff et al., 2006). Ngenxa yoko, kubaluleke kakhulu ukufumana unyango olusebenzayo lwe-CID ye-5-FU.

Okwangoku, ukungenelela okungekho ziyobisi kunye nokungenelela kweziyobisi kuye kwangeniswa kunyango lweklinikhi ye-CID. Ungenelelo olungelulo iziyobisi lubandakanya ukutya okunengqiqo, kunye nokuncedisa ngetyuwa, iswekile kunye nezinye izondlo. Iziyobisi ezifana ne-loperamide kunye ne-octreotide zisetyenziswa ngokuqhelekileyo kwi-anti-diarrhea therapy ye-CID (Benson et al., 2004). Ukongeza, ii-ethnomedicines zikwamkelwe ukunyanga i-CID ngonyango lwazo olulodwa kumazwe ahlukeneyo. Iyeza lemveli laseTshayina (TCM) lilinye eliqhelekileyo le-ethnomedicine eliye lasetyenziswa iminyaka engaphezu kwama-2000 kumazwe aseMpuma Asia kuquka iChina, iJapan kunye neKorea (Qi et al., 2010). I-TCM ibambe ukuba amachiza e-chemotherapeutic angaqalisa ukusetyenziswa kwe-Qi, ukunqongophala kwe-spleen, i-disharmony yesisu kunye nokufuma kwe-endophytic, okukhokelela kukungasebenzi kakuhle kwamathumbu. Kwithiyori ye-TCM, isicwangciso sonyango se-CID kufuneka sixhomekeke ikakhulu ekwandiseni i-Qi kunye nokuqina kwe-spleen (Wang et al., 1994).

Iingcambu ezomileyo zeAtractylodes macrocephalaKoidz. (AM) kunyePanax ginsengCA Mey. (PG) ngamayeza esintu aqhelekileyo kwi-TCM aneziphumo ezifanayo zokongeza i-Qi kunye nokomeleza udakada (Li et al., 2014). I-AM kunye ne-PG zidla ngokusetyenziswa njengezibini zemifuno (eyona ndlela ilula yokuhambelana kwemifuno yaseTshayina) kunye nemiphumo yokongeza i-Qi kunye nokomeleza udaka ukunyanga urhudo. Umzekelo, i-AM kunye ne-PG zibhalwe kwiifomyula zamandulo ezichasene norhudo ezifana noShen Ling Bai Zhu San, uSi Jun Zi Tang osuka.Taiping Huimin Heji Ju Fang(Ubukhosi beNgoma, iChina) kunye noBu Zhong Yi Qi Tang ukusukaUPi Wei Lun(Ubukhosi baseYuan, eChina) (Umfanekiso 1). Izifundo ezininzi zangaphambili zaxela ukuba zonke ezi fomula zintathu zinamandla okunciphisa i-CID (Bai et al., 2017; Chen et al., 2019; Gou et al., 2016). Ukongeza, uphononongo lwethu lwangaphambili lubonise ukuba iShenzhu Capsule equlethe kuphela i-AM kunye ne-PG ineziphumo ezinokubakho kunyango lohudo, i-colitis (i-xiexie syndrome), kunye nezinye izifo zesisu (Feng et al., 2018). Nangona kunjalo, akukho sifundo sixoxe ngesiphumo kunye nendlela ye-AM kunye ne-PG ekunyangeni i-CID, nokuba idibene okanye yodwa.

Ngoku i-gut microbiota ithathwa njengento enokubakho ekuqondeni indlela yonyango ye-TCM (Feng et al., 2019). Uphononongo lwangoku lubonisa ukuba i-gut microbiota idlala indima ebalulekileyo ekugcineni i-homeostasis yamathumbu. Impilo ye-gut microbiota inegalelo ekukhuselweni kwe-mucosal yamathumbu, i-metabolism, i-immune homeostasis kunye nokuphendula, kunye nokunyanzeliswa kwe-pathogen (Thursby noJuge, 2017; Pickard et al., 2017). I-Disordered gut microbiota iphazamisa imisebenzi ye-physiological kunye ne-immune yomzimba womntu ngokuthe ngqo okanye ngokungathanga ngqo, ibangela ukuphendula kwecala elifana nesifo sohudo (uPatel et al., 2016; Zhao kunye noShen, 2010). Uphando lubonise ukuba i-5-FU yatshintsha ngokuphawulekayo isakhiwo se-gut microbiota kwiigundane zohudo (Li et al., 2017). Ngoko ke, imiphumo ye-AM kunye ne-PM kwi-5-FU eyenziwa yi-diarrhea inokuthi ixutywe yi-gut microbiota. Nangona kunjalo, nokuba i-AM kunye ne-PG yodwa kwaye ngokudibeneyo inokuthintela urhudo olubangelwa yi-5-FU ngokumodareyitha i-gut microbiota ayaziwa.

Ukuze siphande iziphumo ezichasene nesifo sohudo kunye nendlela engaphantsi kwe-AM kunye ne-PG, sasebenzisa i-5-FU ukulinganisa imodeli yohudo kwiimpuku. Apha, sigxininise kwimiphumo enokubakho yolawulo olulodwa kunye oludibeneyo (AP) lweAtractylodes macrocephalaioli ebalulekileyo (AMO) kunyePanax ginsengi-saponins iyonke (PGS), amacandelo asebenzayo ngokulandelelana akhutshwe kwi-AM kunye ne-PG, kwisifo sohudo, i-intestinal pathology kunye nesakhiwo se-microbial emva kwe-5-FU i-chemotherapy.