I-100% ye-Oli ecocekileyo yeNdalo ye-Eucommiae yeFoliuml ye-Oli ebalulekileyo yokuKhathalela ulusu

I-100% yeNdalo ecocekileyo ye-Eucommiae ye-Oli yeFoliuml ye-oyile ebalulekileyo yokhathalelo lolusu umfanekiso ofakiweyo

inkcazelo emfutshane:

Eucommia ulmoides(EU) (eqhele ukubizwa ngokuba yi-“Du Zhong” ngolwimi lwesiTshayina) yeyosapho lwe-Eucommiaceae, udidi lomthi omncinane oyinzalelwane kuMbindi we-China [1]. Esi sityalo silinywa kakhulu e-China ngomlinganiselo omkhulu ngenxa yokubaluleka kweyeza. Malunga ne-112 iikhompawundi ziye zahlukaniswa kwi-EU ezibandakanya i-lignans, i-iridoids, i-phenolics, i-steroids, kunye nezinye iikhompawundi. Ifomula yemifuno eyongezelelweyo yesi sityalo (efana neti emnandi) ibonise iimpawu ezithile zonyango. Igqabi le-EU linomsebenzi ophezulu onxulumene ne-cortex, intyatyambo, kunye neziqhamo [2,3]. Amagqabi e-EU axelwe ukuba akhulise amandla amathambo kunye nezihlunu zomzimba [4], nto leyo ekhokelela kubomi obude nokukhuthaza ukuchuma ebantwini [5]. Ifomula yeti emnandi eyenziwe ngegqabi le-EU kuxelwe ukuba yehlisa ukutyeba kunye nokuphucula i-metabolism yamandla. Iikhompawundi zeFlavonoid (ezifana ne-rutin, i-chlorogenic acid, i-ferulic acid, kunye ne-caffeic acid) ziye zaxelwa ukuba zibonisa umsebenzi we-antioxidants kumagqabi e-EU [6].

Nangona kukho uncwadi olwaneleyo kwiipropathi ze-phytochemical ze-EU, zimbalwa izifundo kodwa zikhona kwiipropati ze-pharmacological ze-compounds ezahlukeneyo ezithathwe kumagxolo, imbewu, iziqu, kunye namagqabi e-EU. Eli phepha lokuphonononga liza kucacisa ulwazi oluneenkcukacha malunga neekhompawundi ezahlukeneyo ezikhutshwe kwiindawo ezahlukeneyo (amaxolo, imbewu, isiqu, kunye neqabunga) le-EU kunye nokusetyenziswa okuza kusetyenziswa kwezi zixhobo kwiipropati zokukhuthaza impilo kunye nemigca yenzululwazi yobungqina kwaye ngaloo ndlela unikeze imathiriyeli yereferensi. ukwenzela ukusetyenziswa kwe-EU.

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Thumela i-imeyile kuthi

Iinkcukacha zeMveliso

Iithegi zeMveliso

IiLignans kunye nezinto eziphuma kuzo zizinto eziphambili ze-EU [7]. Ukuza kuthi ga ngoku, ii-lignans ezingama-28 (ezifana ne-bisepoxylignans, monoepoxylignans, neolignans, kunye ne-sesquilignans) ziye zahlukaniswa kumaxolo, amagqabi kunye nembewu ye-EU. I-Iridoid glycoside, iklasi ye-metabolites yesibini, inxalenye yesibini ephambili ye-EU. Iridoids idla ngokufumaneka kwizityalo ezaziwa njenge glycosides. I-iridoids engamashumi amabini anesine iye yahlukaniswa kwaye ichongwa kwi-EU (Uluhlu loku-1). Ezi khompawundi zodwa ziquka i-geniposidic acid, i-aucubin, kunye ne-asperuloside ekuye kwaxelwa ukuba zineempawu ezibanzi ze-pharmacological [8-10]. Iikhompawundi ezimbini ezintsha ze-iridoids, i-Eucommides-A kunye no-C, kutshanje ziye zabekwa zodwa. Ezi zimbini zendalo zithathwa njenge-conjugates ye-iridoid kunye ne-amino acids. Nangona kunjalo, inkqubo ephantsi komsebenzi wabo ayifumaneki [11].

2.2. Phenolic Compounds

Iikhompawundi ze-Phenolic ezithathwe kukutya ziye zaxelwa ukuba zinempembelelo entle kwimpilo yabantu [12,13]. Malunga nama-29 eekhompawundi zephenolic ziye zabekwa zodwa kwaye zachongwa kwi-EU [14]. Umxholo opheleleyo we-phenolic compounds (kwi-gallic acid equivalents kuzo zonke izicatshulwa) zahlaziywa kusetyenziswa i-Folin-Ciocalteu phenol reagent. Iziphumo zokwahluka kwexesha kwimixholo yezinye iikhompawundi kunye ne-antioxidants ziye zaxelwa. Kunyaka ofanayo, iziqulatho eziphezulu ze-phenolics kunye ne-flavonoids zifunyenwe kumagqabi e-EU ngo-Agasti noMeyi, ngokulandelanayo. I-Rutin, i-quercetin, i-geniposidic acid, kunye ne-aucubin bezikho kwindawo ephezulu ngoMeyi okanye ngoJuni.15]. Ngaphezu koko, umsebenzi ophezulu we-1,1-diphenyl-2-picrylhydrazyl (DPPH) umsebenzi wokulahla ngokukhawuleza kunye nobuchule be-metal ion chelating bufunyenwe kumagqabi e-EU avunwe ngo-Agasti. Ukonyuka komxholo wokutya okulwa ne-antioxidants kwakhona kwaxelwa ngoMeyi xa kuthelekiswa namanye amaxesha onyaka [15]. Igqabi le-EU lifunyaniswe lingumthombo otyebileyo we-aminoacids, iivithamini, iiminerali, kunye ne-flavonoids ezifana ne-quercetin, i-rutin, kunye ne-geniposidic acid.11,16]. Iyonke i-7 flavonoids iye yahlukaniswaEucommiaizityalo [17]. IRutin kunye nequercetin zezona flavonoids zibalulekileyo.18]. I-Flavonoids zikhompawundi ezibalulekileyo eziqhelekileyo kwindalo kwaye zithathwa njenge-metabolites yesibini kwaye zisebenza njengezithunywa zeekhemikhali, i-physiological regulators, kunye ne-cell cycle inhibitors.

2.3. Steroids kunye neTerpenoids

I-steroids ezintandathu kunye neeterpenoids ezintlanu ziye zakhutshwa kwaye zahlelwa kwi-EU. Ezi ziqukaβ-sitosterol, daucosterol, ulmoprenol, betalin, betulic acid, ursolic acid, eucommidiol, rehmaglutin C, kunye 1,4α,5,7α-tetrahydro-7-hydroxymethyl-cyclopenta[c]pyran-4-carboxylic methyl ester eyayibekwe yodwa kwixolo le-EU [19]. ILoliolide iye yahlukaniswa namagqabi [20].

2.4. Iipolysaccharides

Iipolysaccharides ezivela kwi-EU iintsuku ze-15 kwi-concentrations ye-300-600 mg / kg zichazwe ukuba zibonise iziphumo zokukhusela kwizintso njengoko zibonwa yi-malonaldehyde kunye namanqanaba e-glutathione emva kokuchithwa kwezintso [21]. Uvavanyo lwe-histological lubonise ubungqina beempawu ze-antioxidative. Izicatshulwa ezivela kwi-bark ye-EU esebenzisa i-ethanol ye-70% nayo ibonise iziphumo zokukhusela kwi-cadmium kwi-125-500 mg / kg [22]. Uviwo lwe-Histological lubonise ukuba i-EU idibenePanax pseudoginsengkwi-25% kunye ne-50% ubunzima, ngokulandelanayo, kwiiveki ezintandathu kwizinga le-dose ye-35.7-41.6 mg / kg yenze iziphumo zokukhusela ezikhanyayo kwi-glomerular filtration rate [8]. Iipolysaccharides ezimbini ezintsha ziye zahlulwa kwi-EU, ezizezi eucomman A kunye no-B [23].

2.5. Ezinye izithako kunye neekhemikhali

I-amino acids, i-microelements, iivithamini, kunye ne-fatty acids nazo ziye zahlukaniswa kwi-EU.17,21-23]. Sun et al. Kwakhona kwafumanisa iikhompawundi ezintsha ezifana ne-n-octacosanoic acid, kunye ne-tetracosanoic-2,3-dihydroxypropylester evela kwi-EU [24].

Ukubunjwa kwe-fatty acid ye-oyile ekhutshwe kwimbewu ye-EU ibonise ukugxininiswa okungafaniyo kwe-polyunsaturated fatty acids ezifana ne-linoleic acid, i-linolenic acid (i-56.51% ye-fatty acids iyonke, i-TFAs), kunye ne-linolelaidic acid (i-12.66% ye-TFAs). Ngeli xesha, i-monounsaturated fatty acid ephambili ebekwe yodwa kwimbewu yafunyanwa i-isoleic acid (15.80% ye-TFAs). I-acids egcweleyo egcweleyo eyongamileyo ibandakanya i-palmitic acid kunye ne-stearic acid emele i-9.82% kunye ne-2.59% yee-TFAs, ngokulandelelanayo.