Ihoyile esulungekileyo yeAtractylodes yeNdalo yeLancea yeOli yeMichiza yeMihla yonke yeHerb Extract Atractylis Oli

pisthorchis viverrini (OV)-induced cholangiocarcinoma (CCA) ngumhlaza oqhelekileyo phakathi kwendoda nebhinqa, ngakumbi eThailand. Uphononongo lwakutsha nje lubonise ukuba isicatshulwa se-ethanol se-AL senza impembelelo yokuthintela kwimodeli yezilwanyana ye-OV-induced CCA ngaphandle kobutyhefu obucacileyo ngolawulo lomlomo iintsuku ezingama-30 ngokweziphumo ezivela kwi-positron emission tomography-computed tomography kunye neehamster zaseSyria zamadoda [7]. Ukuze uhlolisise isiphumo se-AL rhizome kwi-motility yesisu, i-atropine-, i-dopamine-, kunye ne-5-hydroxytryptamine (5-HT)-ephathwe iigundane zamkelwe kwisifundo. Iziphumo zibonise ukuba i-1 mg/kg isicatshulwa sinokucinezela ngokubalulekileyo ukukhupha isisu esibangelwa yi-dopamine kunye nokuhamba kwesisu sokuncipha ngenaliti ye-intraperitoneal. Isicatshulwa kwi-concentration ye-1000 mg / kg inokuthintela ukuhla kwe-atropine-induced intestinal motility encinci, kwaye isicatshulwa se-500 mg / kg idosi inokuthintela ukuphuma kwesisu kwe-5-HT-induced gastric kunye nokunciphisa ukuhamba kwamathumbu amancinci [8]. Ukongezelela, i-AL yenza i-anti-gastric ulcer effect kwimodeli yegundane ngokunciphisa abalamli abavuthayo (okt tumor necrosis factor-α (TNF-α), interleukin-8 (IL-8), IL-6), kunye ne-prostaglandin E2 (PGE2) kunye nokwandisa i-epidermal growth factor (EGF) kunye ne-trefoil factor2 (TFF2) [9]. Iintsholongwane zokungunda ezifumaneka emhlabeni zehlise i-30% yezivuno zamandongomane [10]. Kutshanje, kuye kwaxelwa ukuba ukulinywa kunye namandongomane, i-AL inokucinezela izifo zokungunda ezithwalwa ngumhlaba ngokunqandaI-Fusarium oxysporumukukhula [11]. Ukukhutshwa kwe-petroleum ether (PE) kwi-AL kubonise impembelelo yokuthintela kwi-BGC-823 kunye ne-SGC-7901 iiseli zomhlaza wesisu somntu. Iqhezu le-PE linokubangela i-apoptosis, ukubanjwa komjikelo weseli, kunye notshintsho olunokwenzeka lwe-mitochondrial transmembrane [12]. Ingxelo yakutshanje ibonise ukuba i-MeOH isicatshulwa se-AL sinokunqanda ukuveliswa kwe-nitric oxide (NO) kwi-lipopolysaccharide-stimulated murine macrophage-like RAW264.7 iiseli kwaye yenze i-granulocyte-colony stimulating factor (G-CSF) imfihlo kwiiseli ze-murine eziqhelekileyo ze-colonic epithelial MCE301. HAYI yi-radical yasimahla [13]. Isicatshulwa se-ethanol se-AL senze i-inhibitory effect ebalulekileyo kwi-lipase kunye ne-IC50 9.06 µg / mL kwi-pancreas lipase assay, kwaye ibonise umphumo wokuchasana nokutyeba kwi-fat-fat-induced osity model model kwi-concentration ephezulu ye-500 mg. /ikg [14]. Izicatshulwa zamanzi ezivela kwi-AL zibonise umsebenzi ochasayo ngokuchasene ne-serotonin receptors kunye nefuthe lokuthintela kwi-agonist ekhethiweyo ye-5-HT2A / 2C 1- (2,5-dimethoxy-4-iodophenyl) -2-i-aminopropane-induced head-twitch response kwiigundane. [15]. Izicatshulwa zamanzi ezisuka kwi-AL zinciphisa ubuthi obubangelwa yi-triptolide ngolawulo oluphantsi lwe-hepatic expression ye-CYP3A. Okwangoku, i-AL inokuphucula iziphumo ezichasayo ze-triptolide. Ezi ziphumo zicebise ukuba i-AL inokuthintela ubuthi kwaye yandise umsebenzi wonyango we-triptolide ngokudibanisa.