Ivenkile enkulu ixabiso 100% iPure Forsythiae Fructus oil Relax Aromatherapy Eucalyptus globulus

Ihoyilesi enkulu ixabiso 100% iPure Forsythiae Fructus oil Relax Aromatherapy Eucalyptus globulus Umfanekiso okhoyo

inkcazelo emfutshane:

I-Forsythia ikhula ngokukhawuleza(Thunb.) Vahl. (Intsapho ye-Oleaceae) i-shrub yokuhlobisa, iziqhamo ezisetyenziswa njenge-TCM eyaziwayo "Forsythiae Fructus" (FF) (连翘in Chinese). Iimpawu ze-TCM ze-FF zishwankathelwa njengobukrakra kwi-flavour, kunye nemvelo ebandayo ebandayo kunye nemiphunga, intliziyo okanye i-intestinum meridian distributions (iKhomishoni ye-Pharmacopoeia ye-PRC, i-2015), ezo mpawu zihambelana nokubonakaliswa kwe-TCM echasayo, ngokutsho kwe-Chen. kunye noZhang (2014). Kwi-herbal ye-Shennong, i-FF yayisetyenziselwa unyango lwe-pyrexia, ukuvuvukala, i-gonorrhea, i-carbuncle kunye ne-erysipelas (Cho et al., 2011). Zimbini iintlobo zeFF ezifumanekayo, isiqhamo esiluhlaza esitsha esivuthiweyo esibizwa ngokuba yi “Qingqiao” kunye nesityheli esivuthwe ngokupheleleyo esibizwa ngokuba yi “Laoqiao”. Bobabini basebenza njengemithombo esemthethweni ye-FF, nangona kunjalo, i-Qingqiao isetyenziswa rhoqo kwimimiselo ye-TCM (Jia et al., 2015). Imimandla emikhulu yokuvelisa i-FF yi-Hebei, i-Shaanxi, i-Shanxi, i-Shandong, i-Anhui, i-Henan, i-Hubei, i-Jiangsu (ilinywe) kunye namaPhondo aseSichuan (iBhodi yoHlelo lwe-Flora yase-China, ngo-1978).

Kwi-2015 edition Chinese Pharmacopoeia, i-114 yamalungiselelo amayeza aseTshayina aqukethe i-FF adweliswe, njenge-Shuanghuanglian isisombululo somlomo, i-tablet ye-Yinqiao Jiedu, iipilisi ze-Niuhuang Shangqing, njl (iKhomishini ye-Pharmacopoeia ye-PRC, i-2015). Uphando lwangoku lutyhila i-anti-inflammatory (Kim et al., 2003), i-antioxidant (CC Chen et al., 1999), antibacterial (Han et al., 2012), anti-cancer (Hu et al., 2007), anti -virus (Ko et al., 2005), anti-allergies (Hao et al., 2010), neuroprotective (S. Zhang et al., 2015) iziphumo,njl.Nangona isiqhamo kuphela sisetyenziswa njenge-TCM, ezinye izifundo zichaze i-phytochemistry kunye nemiphumo ye-pharmacological yamagqabi (Ge et al., 2015, Zhang et al., 2015), iintyatyambo (Takizawa et al., 1981) kunye nembewu (Zhang et al. ., 2002) yeF. suspensa. Ke ngoko, ngoku sibonelela ngombono ocwangcisiweyo wolwazi olukhoyo lweF. suspensa, kubandakanywa ukusetyenziswa kwendabuko, ibhotani, i-phytochemistry, i-pharmacology, i-toxicity, i-pharmacokinetics kunye nokulawula umgangatho. Kwakhona, imikhomba-ndlela enokubakho yophando iyaxoxwa.

Iziqwengana zecandelo

Usetyenziso lwemveli

Kwimibhalo yamandulo yaseTshayina, i-FF irekhodwa njengeluncedo kunyango lwe-rat fistula, i-scrofula, i-carbuncle, isilonda esibi, i-gall tumor, ukushisa kunye netyhefu (i-Shennong's herbal, i-Bencao Chongyuan, i-Bencao Zhengyi, i-Zhenglei Bencao). Ngokweeklasikhi ezininzi zakudala, esi sityalo sonyango sisebenza kakhulu ekucoceni ubushushu betshaneli yentliziyo kunye nokukhulula ukufuma-ubushushu bespleen kunye nesisu. Ikwayinto yonyango kunyango lwe-stranguria, i-edema, i-qi stagnancy kunye ne-blood stasis.

Izityalo

F. suspensa(I-Weeping Forsythia) sisihlahla esihonjisiweyo esinamagqabi avuthuluka eTshayina, sikhula sibe kubude obumalunga ne-3 m (Umfanekiso 1). Inee internodes ezinabileyo ezinabileyo okanye ezinabileyo ezityheli-mdaka okanye ngwevu-mdaka ngombala. Amagqabi adla ngokuba lula, kodwa ngamanye amaxesha abe 3-foliolate. Amagqabi amagqabi ane-ovate, ngokubanzi, okanye i-elliptic-ovate kunye ne-2-10 × 1.5-5 cm2 ngobukhulu kunye nesiseko esijikelezileyo ukuya kwi-cuneate kunye ne-apex ebukhali. Omabini amacala amagqabi aluhlaza, akhazimle ngokubukhali okanye ngokurhabaxa

IPhytochemistry

Namhlanje, iikhompawundi ezingama-237 zifunyenweF. suspensa, kubandakanywa i-46 lignans (1-46), i-31 phenylethanoid glycosides (47-77), i-11 flavonoids (78-88), i-80 terpenoids (89-168), i-20 ye-cyclohexylethanol derivatives (169-188), i-alkaloids ezintandathu (i-alkaloids) ezintandathu (1948) ), ezine steroidal (195-198) kunye ne-39 nezinye iikhompawundi (199-237). Phakathi kwabo, amacandelo amabini (21-22) ahlukanisiwe kwiintyatyambo zeF. suspensa, Amacandelo ali-19 (94–100, 107–111, 115–117, 198, 233–235) aye ahlukaniswa kumagqabi eF. suspensa, imiba emine

Iziphumo ezichasayo

Imisebenzi ye-Anti-inflammatory ye-FF ixhasa imiphumo yayo yokucoca ukushisa (Guo et al., 2015). Ukuvuvukala kukuphendula ngokomzimba kwi-infectious, i-allergic, okanye i-chemical stimulation (Lee et al., 2011). Ibandakanyeka ekuphuhliseni izifo ezingapheliyo, ezifana nezifo zesikhumba, i-allergies, kunye nomhlaza,njl.I-FF yenye ye-TCM enegunya elinamandla lokuchasa ukudumba, isetyenziswa ngokubanzi kukuvuvukala okungapheliyo kunye nokukhawuleza. Imisebenzi yokulwa nokudumba kwe-FF ibeka phezulu ezintlanu phakathi kwe-81 evavanyiweyo ye-TCM (i-70% ye-ethanol

Ubutyhefu

Ukuza kuthi ga ngoku, akukho ngxelo malunga nobutyhefu beFF. I-dose yokulawula imihla ngemihla ye-FF icetyiswa ukuba ibe yi-6-15 g (iKhomishini ye-Pharmacopoeia ye-PRC, i-2015). Iingxelo ezifanelekileyo zibonise ukuba akukho tyhefu ebukhali yamanzi okanye isicatshulwa se-ethanol samagqabiF. suspensakwiimpuku, nakwidosi yemihla ngemihla ye-61.60 g / kg (Ai et al., 2011, Hou et al., 2016, Li et al., 2013). Han et al. (2017) ingxelo akukho tyhefu ebukhali phillyrin (ukusuka emagqabiniF. suspensa)kwiimpuku ze-NIH (18.1 g / kg / ngosuku, po, iintsuku ze-14) okanye akukho

Pharmacokinetics

Li et al. ichonge inqanaba elisithoba le-metabolites ye-phillyrin kwiisampulu zomchamo weempuku kwaye ibonise iindlela zayo ezinokuthi zenzeke kwiimpuku. I-Phillyrin yaqala i-hydrolyzed kwi-phillygenin kwaye emva koko yaguqulelwa kwezinye i-metabolites ngokugqithiseleyo nge-methylation, i-demethylation, i-dehydroxylation kunye neenkqubo zokuvula i-ring-ring (Li et al., 2014c). H. Wang et al. (2016) ichonge i-34 isigaba I kunye nesigaba se-II metabolites se-phillyrin kwaye ibonise ukuba i-hydrolysis, i-oxidation kunye ne-sulfation yayinkulu.

Ulawulo lwemeko

Ukulawula umgangatho we-FF, i-Pharmacopoeia yaseTshayina iphakamisa ukuchongwa kwe-morphological, microscopic kunye ne-TLC ngaphezu kokuzimisela kwe-HPLC. Iisampulu ze-FF ezifanelekayo kufuneka zibe ngaphezu kwe-0.150% phillyrin (iKhomishini ye-Pharmacopoeia ye-PRC, i-2015).

Nangona kunjalo, i-quantitative marker enye, i-phillyrin, ibonakala ingonelanga ukuvavanya umgangatho we-FF. Kutshanje, iinxalenye ezahlukeneyo ze-bioactive kwi-FF ziye zavavanywa nge-chromatography eyahlukileyo, i-electrophoresis, i-MS kunye neendlela ze-NMR, ezifana

Isiphelo kunye neembono zexesha elizayo

Uphononongo lwangoku lushwankathela ulwazi olubanzi malunga nokusetyenziswa kwemveli, ibhotani, i-phytochemistry, iziphumo zamayeza, ubuthi, i-pharmacokinetics kunye nolawulo lomgangatho weF. suspensa. Kwimibhalo yesiShayina yamandulo kunye ne-Chinese Pharmacopoeia, i-FF isetyenziswa kakhulu ekucoceni ubushushu kunye nokukhupha ityhefu. Ukuza kuthi ga ngoku, ngaphezu kwama-230 iikhompawundi ziye zahlulwa kwaye zachongwa kule mifuno. Phakathi kwabo, i-lignans kunye ne-phenylethanoid glycosides zibhekwa njengempawu kunye ne-bioactive

TCM iinkcazelo

Yin: "Yin" yenye yamandla amabini achaseneyo endalo, ngokolwakhiwo lwamandulo lwaseTshayina lwendalo iphela. "I-Yin" ibonakaliswe njengecothayo, ithambileyo, inikezela, isasazeka, ibanda, imanzi okanye izolile, kwaye inxulunyaniswa namanzi, umhlaba, inyanga, ubufazi kunye nexesha lasebusuku.

Qi: Ngokwemigaqo ye-acupuncture, "qi" "ngamandla obomi". Ingumthombo wayo yonke intshukumo ngaphakathi emzimbeni, ukukhuselwa ekuhlaselweni komzimba, umthombo wayo yonke imisebenzi ye-metabolic, ibonelela ngokubamba izicubu.

Imibulelo

Lo msebenzi uxhaswe yiBeijing Joint Project yoPhando lweSayensi kunye nemfundo yasemva kwesidanga-Uphando lwetekhnoloji engundoqo kunye nokusetyenziswa kovavanyo lokhuseleko lwemathiriyeli eyityhefu yamayeza aseTshayina esekwe kubume bemichiza kunye neempawu zezebrafish.

FOB Ixabiso:US $ 0.5 - 9,999 / Iqhekeza

Min.Ubungakanani boMyalelo:100 Iqhekeza / Iingceba

Ubunakho bokubonelela:10000 Iqhekeza/Amaqhekeza ngenyanga

Thumela i-imeyile kuthi

Iinkcukacha zeMveliso

Iithegi zeMveliso

Ukufaneleka kwe-Ethnopharmacological

Forsythiae Fructus (ebizwa ngokuba Lianqiao ngesiTshayina), isiqhamoI-Forsythia ikhula ngokukhawuleza(Thunb.) Vahl, isetyenziswa njengeyeza lesintu eliqhelekileyo eTshayina, eJapan naseKorea. Ngokuqhelekileyo isetyenziselwa ukunyanga i-pyrexia, ukuvuvukala,i-gonorrhea,i-carbunclekwayei-erysipelas. Kuxhomekeke kwixesha lokuvuna elahlukileyo, iForsythiae Fructus ingahlelwa ngokweendlela ezimbini, ezizezi, Qingqiao kunye neLaoqiao. Iziqhamo eziluhlaza eziqala ukuvuthwa ziqokelelwa njengeQingqiao, ngelixa iziqhamo ezityheli ezivuthwe ngokupheleleyo ziqokelelwa njengeLaoqiao. Zombini zisetyenziselwa ukusetyenziswa kwezonyango. Olu phononongo lujolise ekuboneleleni ngesishwankathelo esicwangcisiweyo seF. suspensa(I-Forsythia ikhula ngokukhawuleza(Thunb.) Vahl) kunye nokutyhila unxulumano phakathi kokusetyenziswa kwemveli kunyeimisebenzi yamachizaukuze unikeze inkuthazo kuphando lwexesha elizayo.

Impahla nenkqubo

Lonke ulwazi oluhambelanayo malungaF. suspensayakhangelwa nguScifinder kwaye yafunyanwa kugcino lweenkcukacha zenzululwazi kuquka iSpringer, Science Direct, Wiley, Pubmed kunye neChina Knowledge Resource Integrated (CNKI). Iincwadi zasekuhlaleni kunye neencwadi zazikhangelwa nazo.

Iziphumo

Ngokwemibhalo yakudala yaseTshayina kunye neFarmacopoeia yaseTshayina, iForsythiae Fructus ibonakalisa kakhulu ukucoca ubushushu kunye neziphumo zokukhupha ubuthiTCMimiyalelo. Kuphando lwangoku, ngaphezu kwe-230 iikhompawundi zahlulwa kwaye zachongwaF. suspensa. 211 Kubo babebodwa kwiziqhamo.Lignanskunye nephenylethanoidglycosideszithathwa njengeempawu kunye nezinto ezisebenzayo zalo myeza, njengeforsythiaside, phillyrin,irutinkunye phillygenin. Babonise i-anti-inflammatory, antioxidant, antibacterial, anti-virus, anti-cancer kunye ne-anti-allergies,njl.Okwangoku, akukho ngxelo malunga netyhefu ye-Forsythiae Fructus, ngaphandle kwetyhefu encinci ye-forsythiaside echazwe kupapasho lwasekhaya. Xa kuthelekiswa neLaoqiao, iQingqiao iqulathe amanqanaba aphezulu eforsythiaside, forsythoside C, cornoside,irutin, phillyrin,igallic acidkwayei-chlorogenic acidkunye namanqanaba asezantsi e-rengyol,β-glucose kunye ne-S-suspensasideimethyl ether.

Ukuqukumbela

Izenzo zokucoca ubushushu zeForsythiae Fructus zisekwe kwipropathi echasayo kunye ne-antioxidant ye-lignans kunye ne-phenylethanoid.glycosides. Iziphumo zokuphelisa ubutyhefu zibangelwa yi-antibacterial, antiviral kunye ne-anti-cancer imisebenzi ye-Forsythiae Fructus. Kwaye amayeza emveli aseTshayina (TCM) iimpawu ze-Forsythiae Fructus (incasa ekrakra, indalo ebanda kancinci kunye ne-lung meridian) ixhase iziphumo zayo ezinamandla zokuchasa ukudumba. Ukongezelela, i-anti-inflammatory ephawulekayo kunyeamandla antioxidantyeForsythiae Fructus inegalelo ekulweni nomhlaza kunyeneuroprotectiveimisebenzi. Ubungakanani obuphezulu be-lignans kunye ne-phenylethanoid glycosides eQingqiao kuneLaoqiao inokuchaza amandla angcono e-antioxidant eQingqiao kunye nokusetyenziswa rhoqo kweQingqiaoTCMimiyalelo. Kuphando lwexesha elizayo, ngaphezulukwi vivoimifuniselo kunye nezifundo zeklinikhi ziyakhuthazwa ukuba zicacise ngakumbi ubudlelwane phakathi kokusetyenziswa kwemveli kunye nezicelo zanamhlanje. Ngokubhekiselele kwiQingqiao kunye neLaoqiao, zihlala zihlukaniswa ngeendlela ezijikelezayo zokulawula umgangatho, kunye nokwakheka kweekhemikhali kunye neziphumo zeklinikhi phakathi kwazo kufuneka zithelekiswe.