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Ioyile ecocekileyo eneBranded enevumba elimnandi yekhandlela kunye nesepha yenza i-oyile ethengisayo idiffuser ebalulekileyo entsha kwizitshisi zengcongolo.

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Ukuqulunqwa kweekhemikhali ze-ATR

Ukubunjwa kweekhemikhali ze-ATR zizinto eziphambili eziguquguqukayo kunye namacandelo angaguqukiyo. Ioli ye-ATR ebalulekileyo (ATEO) ithathwa njengento esebenzayo ye-ATR, kwaye umxholo we-ATEO kuphela kwesalathisi sokumiselwa komxholo we-ATR. Okwangoku, kukho uphando olwahlukeneyo kumalungu aguquguqukayo kunye nophando oluncinci kumalungu angaguquguqukiyo. Amacandelo aguquguqukayo anzima, kwaye iindidi eziphambili zesakhiwo ziyi-phenylpropanoids (i-phenylpropanoids elula, i-lignans kunye ne-coumarins) kunye ne-terpenoids (i-monoterpenes, i-sesquiterpenes, i-diterpenoids kunye ne-triterpenes). Amalungu angaguquguqukiyo ikakhulu ziialkaloids, aldehydes kunye neeasidi, iiquinones kunye neeketones, iisterols, amino acids, kunye neecarbohydrates. Iziphumo zophononongo lwe-ATR yokwakheka kweekhemikhali ziya kuba negalelo kuphuhliso lophando lomgangatho walo.

Ukuqulunqwa okuguquguqukayo

Abaphandi basebenzise iindlela zokuvavanya uhlalutyo ezifana ne-chromatography kunye ne-GC-MS ukuhlalutya iikhemikhali ze-ATR ezivela kwimvelaphi eyahlukeneyo, iibhetshi ezahlukeneyo, iindlela ezahlukeneyo zokutsalwa kunye namacandelo ahlukeneyo. Uphononongo lwangaphambili lubonise ukuba iikhemikhali eziphambili ze-ATR zaziyi-oyile eguquguqukayo, eyona nto ibalulekileyo yokuvavanya umgangatho we-ATR. I-α-Asarone kunye ne-β-asarone ibalwa kwi-95% ye-ATR yeoli eguquguqukayo kwaye ichongiwe njengamacandelo empawu (Umfanekiso woku-1) (Lam et al., 2016a). I-"Pharmacopoeia yeRiphabhlikhi yaBantu baseChina" (uHlelo lwe-2020) irekhoda ukuba umxholo we-oyile oguquguqukayo we-ATR akufanele ube ngaphantsi kwe-1.0% (mL/g). Okwangoku, iintlobo ezininzi ze-oyile eziguquguqukayo zifunyenwe kwi-ATR


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  • Iinkcukacha zeMveliso

    Iithegi zeMveliso

    Acori TatarinowiiI-Rhizoma (ATR,Shi Chang PungesiTshayina) yirhizome eyomileyoAcorus tatarinowiiSchott., isityalo esingapheliyo seAraceae Juss (Yan et al., 2020b). Ibhalwe okokuqala kwimisebenzi yakudala yamayeza emveli aseTshayina "iShen Nong's Materia Medica," kwaye idweliswe njengebakala eliphezulu. Iziphumo ze-ATR ikakhulu kukuvuselela, ukuzola ingqondo, ukusombululaShi(ubumanzi) kwaye ulungelelanise iwena(isisu) (Lam et al., 2016b). Ngokweklinikhi, i-ATR isetyenziselwa ngokubanzi ukuphazamiseka kwe-neurological, inkqubo ye-cardiovascular system, inkqubo yokugaya isisu, inkqubo yokuphefumula e-China (Lam et al., 2016b;Li et al., 2018a) kunye nokunyangwa kwesifo sokuwa, ukudandatheka, i-amnesia, ingqondo, ixhala, ukulala, i-aphasia, i-tinnitus, i-cancer, i-dementia, i-stroke, izifo zesikhumba kunye nezinye izifo ezinzima (U-Lee et al., ngo-2004;Liu et al., 2013;Lam et al., ngo-2019;Li J. et al., 2021). Kwiminyaka yakutshanje, uphando lwayo lwe-pharmacological lubonise ukuba i-ATR ineempembelelo ezahlukeneyo ze-pharmacological, ezibandakanya i-anti-epileptic, i-sedative, i-hypnotic, i-anti-convulsant, i-anti-tussive, i-anti-asthmatic, i-anti-oxidant, i-anti-tumor kunye nokunye.Wu et al., 2015;Lam et al., 2017a;Fu et al., ngo-2020;Shi et al., 2020;UZhang W. et al., 2022). Uphononongo lwangaphambili lubonise ukuba i-ATR iyathembisa njengomgqatswa weziyobisi onokubakho kunyango lwe-Alzheimer's disease (AD), ukudakumba, okanye ukudumba kwesilonda esiswini. Ngokujonga ngokuthe ngqo ukusebenza kweklinikhi ye-ATR kunye nokufunyanwa okuqhubekayo kwemisebenzi emitsha ye-pharmacological kunye nezithako ezisebenzayo, ixhalabele ngokubanzi kwihlabathi jikelele kwiminyaka yamuva kwaye ibe yenye yeentlobo zeyeza zaseTshayina eziphandiweyo kwintsimi yezonyango.

    Ukwakhiwa kweekhemikhali kunye nemiphumo ye-pharmacological ye-ATR iye yaxelwa ngokubanzi kwiminyaka embalwa edlulileyo, kwaye i-pharmacokinetics yayo kunye ne-toxicity nayo ifundwe ngamaqondo ahlukeneyo. Nangona kunjalo, uninzi lweengxelo zangaphambili zihlakazekile, azikho isishwankathelo esicwangcisiweyo kunye nokungeniswa kwe-ATR. Ngoko ke, olu hlaziyo lujolise ekuboneleleni isishwankathelo esibanzi kunye nengxoxo yokwakheka kweekhemikhali, i-pharmacology, i-pharmacokinetics kunye neempawu ze-toxicity, ngaloo ndlela igalelo kwintsebenzo yeklinikhi eqhubekayo kunye nokusetyenziswa kwe-ATR.








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