Pure zendalo eziphilayo magnolia kubalulekile oyile flos magnoliae ioli ioli yesiqholo

Pure zendalo eziphilayo magnolia kubalulekile oyile flos magnoliae ioli isiqhumiso oyile Featured Umfanekiso

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IMagnoliae Flos yinto eqhelekileyo esetyenziswa ngamayeza esintu eAsia. Isetyenziselwa ukunyanga i-sinusitis, ukuxinana kweempumlo, kunye nolusu lwe-hypersensitive. Ngenxa yokuba iMagonlia Flos yayichazwa njengesixhobo esinevumba elimnandi kwimibhalo yakudala yaseTshayina, saqikelela ukuba ioyile yayo eyimfuneko inokusetyenziselwa ukunyanga izifo zokhuselo lomzimba. Iiseli ze-Dendritic (i-DCs), ezithathwa njengeyona njongo iphambili ye-immunomodulators ukulawula iimpendulo ze-immune, zidlala indima ebalulekileyo kwi-adaptive immune response. Kulo cwaningo, i-Magnoliae Flos ioli ebalulekileyo (i-MFEO) iyancipha ukuveliswa kwe-cytokines TNF-α, IL-6, kunye ne-IL-12p70 kwi-lipopolysaccharide (LPS) -i-DCs evuselelwe. Ikwacinezela iziphawuli ezingaphezulu kwe-MHC II, i-CD80, kunye ne-CD86 kwii-DCs ezivuselelweyo ze-LPS. Iimodeli zezilwanyana zibonise ukuba i-2,4-Dinitro-1-fluorobenzene (DNFB) ibangela ukuba impendulo ye-hypersensitivity yoqhagamshelwano yayithintelwe emva konyango kunye ne-MFEO. Ukongezelela, i-MFEO ivimbele ukungena kweeseli ze-T ezindlebeni ze-DNFB-induced mice. Ukuphonononga iikhompawundi zayo ze-bioactive, amacandelo e-MFEO ahlalutywa ngokusebenzisa i-chromatography yegesi (GC) kunye ne-GC-mass spectrometry. Iziphumo zibonise ukuba iikhompawundi ezinkulu kwi-MFEO ziyi-camphor kunye ne-1,8-cineole. Uvavanyo olongezelelweyo lwe-DC luqinisekisile ukuba ezi khompawundi zicinezele kakhulu imveliso ye-cytokine kwii-DCs ezenziwe nge-LPS. Ngoko ke, sibonise ukuba i-MFEO ibonisa i-immunosuppressive effect zombini kwi-vivo kunye ne-vitro, kunye ne-camphor kunye ne-1,8-cineole ingaba ngamacandelo amakhulu ajongene nekhono layo lokukhusela. Iziphumo zibonisa ukuba i-MFEO inamandla okuphuhliswa njenge-immunosuppressant entsha yezifo ezigqithisileyo.

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, IL-6, kunye ne-IL-12p70 kwi-lipopolysaccharide (LPS) -i-DCs evuselelweyo. Ikwacinezela iziphawuli ezingaphezulu kwe-MHC II, i-CD80, kunye ne-CD86 kwii-DCs ezivuselelweyo ze-LPS. Iimodeli zezilwanyana zibonise ukuba i-2,4-Dinitro-1-fluorobenzene (DNFB) ibangela ukuba impendulo ye-hypersensitivity yoqhagamshelwano yayithintelwe emva konyango kunye ne-MFEO. Ukongezelela, i-MFEO ivimbele ukungena kweeseli ze-T ezindlebeni ze-DNFB-induced mice. Ukuphonononga iikhompawundi zayo ze-bioactive, amacandelo e-MFEO ahlalutywa ngokusebenzisa i-chromatography yegesi (GC) kunye ne-GC-mass spectrometry. Iziphumo zibonise ukuba iikhompawundi ezinkulu kwi-MFEO ziyi-camphor kunye ne-1,8-cineole. Uvavanyo olongezelelweyo lwe-DC luqinisekisile ukuba ezi khompawundi zicinezele kakhulu imveliso ye-cytokine kwii-DCs ezenziwe nge-LPS. Ke ngoko, sibonise ukuba i-MFEO ibonisa i-immunosuppressive effect zombinikwi vivokwayei-In vitro, kunye ne-camphor kunye ne-1,8-cineole ingaba ngamacandelo amakhulu ajongene nekhono layo lokukhusela i-immunosuppressive. Iziphumo zibonisa ukuba i-MFEO inamandla okuphuhliswa njenge-immunosuppressant entsha yezifo ezigqithisileyo.