Ioli yeYlang-ylang

Ylang-ylangi-oyile ebalulekileyo (YEO), efunyenwe kwiintyatyambo zomthi wetropikiCanangaivumbaHook. f. kunye noThomson (usaphoAnnonaceae), isetyenziswe kakhulu kumayeza esintu kunye nokusetyenziswa okuninzi, kubandakanywa ukuxhalaba kunye nokuguqulwa kwe-neuronal states. Intlungu ye-neuropathic yimeko yentlungu engapheliyo kunye neziganeko eziphezulu ze-comorbidities, ezifana nokuxhalaba, ukuxinezeleka, kunye nezinye iingxaki zengqondo, ezichaphazela kakhulu umgangatho wobomi besigulane. Amachiza akhoyo ngoku asetyenziselwa ukulawula intlungu ye-neuropathic ayanelanga ngenxa yokungasebenzi kakuhle kunye nokunyamezela, ukugxininisa imfuno yonyango ye-pharmacotherapy engcono. Izifundo ezininzi zeklinikhi ziye zaxela ukuba i-massage okanye ukuphefumla ngeeoyile ezikhethiweyo eziyimfuneko kunciphisa iimpawu ezinxulumene neentlungu kunye nokuxhalaba.

Injongo yolu phononongo yayikukuphanda iipropati ze-analgesicYEOkunye nokusebenza kwayo ekunciphiseni ukuguquka kwemizwelo okuhambelana ne-neuropathy.

Iipropathi ze-analgesic zavavanywa kwimodeli yokulimala kwe-nerve egciniweyo kusetyenziswa iimpuku zamadoda. I-anxiolytic, antidepressant, kunye nepropathi ye-locomotor nazo zavavanywa kusetyenziswa iimvavanyo zokuziphatha. Ekugqibeleni, indlela yokusebenza ye-YEO yaphandwa kwintambo yomgogodla kunye ne-hippocampus yeempuku ze-neuropathic.

Ulawulo lomlomo lweYEO(30 mg / kg) yanciphisa intlungu ye-neuropathic eyenziwe yi-SNI kwaye iphucula iimpawu ezixhalabisayo ezinxulumene nentlungu ebonakala kwiintsuku ze-28 emva kokuhlinzwa.YEOukunciphisa ukubonakaliswa kwee-MAPKs, i-NOS2, i-p-p65, iimpawu ze-neuroinflammation, kunye nokukhuthaza isiphumo esiqhelekileyo kumanqanaba e-neurotrophin.

YEOI-neuropathic i-induced pain relief kunye nexhala elihambelana nentlungu, emele umviwa onomdla wokulawula iimeko zentlungu ye-neuropathic kunye ne-comorbidities ezinxulumene nentlungu.