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Ihoyile esulungekileyo yeAtractylodes yeNdalo yeLancea yeOli yeMichiza yeMihla yonke yeHerb Extract Atractylis Oli
IMIQATHANGO YOKUSETYENZISWA KUNYE NOLWAZI OLUBALULEKILEYO: Olu lwazi lwenzelwe ukuncedisana, kungekhona indawo yengcebiso evela kugqirha wakho okanye kumboneleli wezempilo kwaye ayenzelwanga ukugubungela konke ukusetyenziswa okunokwenzeka, izilumkiso, ukusebenzisana okanye iziphumo ezibi. Olu lwazi lusenokungafanelanga iimeko zakho ezithile zempilo. Ungaze ulibazise okanye ungakuhoyi ukufuna iingcebiso zobugqirha kugqirha wakho okanye komnye umboneleli wezempilo ofanelekileyo ngenxa yento oyifundileyo kwiWebMD. Kufuneka uhlale uthetha nogqirha wakho okanye uchwepheshe wezempilo ngaphambi kokuba uqale, uyeke, okanye utshintshe nayiphi na inxalenye emiselweyo yesicwangciso sakho sokhathalelo lwempilo okanye unyango kwaye ufumanise ukuba yeyiphi ikhosi yonyango ekulungeleyo.
Esi sixhobo se-copyright sinikezelwa yi-Natural Medicines Comprehensive Database Consumer Version. Ulwazi oluvela kulo mthombo lusekelwe kubungqina kunye nenjongo, kwaye ngaphandle kwempembelelo yorhwebo. Ngolwazi lwezonyango lobuchwephesha kumayeza endalo, jonga Amayeza eNdalo aBanzi beDatabase yeNguqulelo yobuNgcali.
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Ihoyile esulungekileyo yeAtractylodes yeNdalo yeLancea yeOli yeMichiza yeMihla yonke yeHerb Extract Atractylis Oli
Yintoni iAtractylodes lancea root extract?
IAtractylodes lancea yimvelaphi yaseTshayina, isityalo esinexabiso lamayeza, esilinywa ngenxa yerhizomes. I-rhizomes yayo iqulethe ioli efunekayo.
Ukusetyenziswa kunye neeNzuzo:
Inezixhobo ezichasayo, ithambisa ulusu xa isetyenziswa. Inokuba luncedo kwi-acne ethambileyo, ulusu olunomsindo.
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Menthol CamphorBorneol Oyile Content Kuba Bath kunye Aromatherapy
IiNzuzo zeMpilo kunye nokuSetyenziswa
I-Borneol ibonelela ngendlela eluncedo kakhulu yokudibana kumayeza aseNtshona naseMpuma. Umphumo weBorneol uxhaphake kakhulu kunyango lwezifo ezahlukahlukeneyo. Kumayeza aseTshayina, inxulunyaniswa nesibindi, i-spleen meridians, intliziyo kunye nemiphunga. Ngezantsi kuluhlu lwezinye zeenzuzo zayo ezininzi zempilo.
Ulwa nesifo sokuphefumla kunye nesifo semiphunga
Izifundo ezininzi zibonisa i-terpenes, kunye ne-Borneol, ngakumbi, zinciphisa ngokufanelekileyo ukugula kokuphefumla. I-Borneol iyeubonise ukusebenza kakuhleekunciphiseni ukuvuvukala kwemiphunga ngokunciphisa i-cytokines evuthayo kunye nokungena kwe-infiltration. Abantu abasebenzisa amayeza aseTshayina baqhele ukusebenzisa iBorneol ukunyanga ibronchitis kunye nezigulo ezifanayo.
Iimpawu ze-Anticancer
I-Borneol nayo ibonisileiipropati ze-anticancerngokunyusa isenzo se-Selenocysteine (SeC). Oku kunciphise ukusasazeka komhlaza ngokufa kweseli yomhlaza ye-apoptotic (ecwangcisiweyo). Kwizifundo ezininzi, i-Borneol ikwabonise ukonyuka kokusebenza kakuhleUkujoliswa kweziyobisi ze-antitumor.
I-analgesic esebenzayo
Kwifundaukuqwalasela intlungu emva kokuhlinzwa kubantu, isicelo se-topical Borneol sikhokelela ekunciphiseni okukhulu kweentlungu xa kuthelekiswa neqela lokulawula i-placebo. Ukongeza, ii-acupuncturists zikholisa ukusebenzisa i-Borneol ngokwezihloko kwiipropathi zayo zokuthoba intlungu.
Isenzo esichasayo
I-Borneol iyebonisiweukuthintela iziteshi ezithile ze-ion ezikhuthaza ukuvuselela intlungu kunye nokuvuvukala. Ikwanceda ekupheliseni intlungu kwizifo ezivuthayo ezifanairheumatoid arthritis.
Iziphumo ze-neuroprotective
I-Borneol inikeza ukhuseleko oluthile ukusukaukufa kweeseli ze-neuronalkwimeko ye-ischemic stroke. Ikwaququzelela ukuvuselelwa kwezicubu zengqondo kunye nokulungiswa. Kucetywa ukuba kubekho le mpembelelo ye-neuroprotective ngokutshintsha ukunyanzeliswa kwe-umqobo wegazi-ubuchopho.
Ulwa noxinzelelo kunye nokudinwa
Abanye abasebenzisi beentlobo ze-cannabis ezinamanqanaba aphezulu e-Borneol bacebisa ukuba iyancipha amanqanaba abo oxinzelelo kwaye inciphise ukudinwa, ke ngoko, ivumela imeko yokuphumla ngaphandle kokuthotywa ngokupheleleyo. Abantu abasebenzisa iChina Medicine nabo bayavumaamandla ayo okuphelisa uxinzelelol.
Impembelelo yeentourage
Njengakwezinye i-terpenes, iziphumo zeBorneol ngokudityaniswa ne-cannabinoids ye-cannabis ziboniseimpembelelo yeqela.Oku kwenzeka xa iikhompawundi zisebenzisana ukunika uncedo oluphakamileyo lonyango. I-Borneol inokonyusa umqobo wegazi-ingqondo, ivumela ukudlula lula kweemolekyuli zonyango kwinkqubo yemithambo-luvo.
Ngaphandle kokusetyenziswa kwamayeza amaninzi e-Borneol, ikwasetyenziswa ngokuqhelekileyo kwizinto ezigxotha izinambuzane ngenxa yobutyhefu bayo bendalo kwiibhugi ezininzi. Iziqholo zikwasebenzisa iBorneol ngenxa yevumba layo elimnandi ebantwini.
Imingcipheko enokubakho kunye neziphumo ebezingalindelekanga
I-Borneol ihlala ithathwa njenge-terpene yesibini kwi-cannabis, okuthetha ukuba ibonakala ngokwexabiso elincinci. La mayeza asezantsi e-Borneol kucingelwa ukuba akhuselekile noko. Nangona kunjalo, kwiidosi eziphezulu ezizimeleyo okanye ukuvezwa kwexesha elide, iBorneol inokuba nayoiingozi ezinokubakho kunye neziphumo ebezingalindelekanga, kuquka:
- Ukucaphuka kwesikhumba
- Ukucaphuka kwempumlo nomqala
- Intloko ebuhlungu
- Isicaphucaphu kunye nokugabha
- Isiyezi
- Ukukhanya-intloko
- Ukufa isiqaqa
Ngokuvezwa okuphezulu kakhulu kweBorneol, abantu banokufumana:
- Ukungazinzi
- Ukuphazamiseka
- Ukungakhathaleli
- Ukuxhuzula
- Ukuba iginyiwe, inokuba yingozi kakhulu
Kubalulekile ukuba uqaphele ukuba imali ekhoyo kwi-cannabis ayinakwenzeka ukuba ibangele ezi mpawu. Ukucaphuka kwakhona akwenzeki kunye needosi ezincinci ezisetyenziselwa i-analgesia kunye nezinye iziphumo.
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Ioyile yeCnidii Fructus esulungekileyo yekhandlela kunye nesepha yenza i-oyile ethengisayo idiffuser ebalulekileyo entsha kwizitshisi zengcongolo.
I-Cnidium sisityalo esiphuma eTshayina. Kwakhona kuye kwafunyanwa e-US e-Oregon. Isiqhamo, imbewu kunye nezinye iinxalenye zezityalo zisetyenziswa njengeyeza.
I-Cnidium isetyenziswe kwi-Traditional Chinese Medicine (TCM) kangangamawaka eminyaka, rhoqo kwiimeko zesikhumba. Akumangalisi ukuba i-cnidium iyisithako esiqhelekileyo kwi-lotions yaseTshayina, i-creams, kunye namafutha.
Abantu bathatha i-cnidium ngomlomo ukunyusa ukusebenza kwezesondo kunye ne-sex drive, kunye nokunyanga i-erectile dysfunction (ED). I-Cnidium isetyenziselwa ubunzima bokuba nabantwana (ukungabi nabantwana), ukwakha umzimba, umhlaza, amathambo abuthathaka (i-osteoporosis), kunye nosulelo lomngundo kunye nebhaktheriya. Abanye abantu bayithatha ukuze banyuse amandla.
I-Cnidium isetyenziswa ngokuthe ngqo esikhumbeni ngenxa yokurhawuzelela, irhashalala, i-eczema, kunye ne-ringworm.
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Ioyile ecocekileyo eneBranded enevumba elimnandi yekhandlela kunye nesepha yenza i-oyile ethengisayo idiffuser ebalulekileyo entsha kwizitshisi zengcongolo.
Ukuqulunqwa kweekhemikhali ze-ATR
Ukubunjwa kweekhemikhali ze-ATR zizinto eziphambili eziguquguqukayo kunye namacandelo angaguqukiyo. Ioli ye-ATR ebalulekileyo (ATEO) ithathwa njengento esebenzayo ye-ATR, kwaye umxholo we-ATEO kuphela kwesalathisi sokumiselwa komxholo we-ATR. Okwangoku, kukho uphando olwahlukeneyo kumalungu aguquguqukayo kunye nophando oluncinci kumalungu angaguquguqukiyo. Amacandelo aguquguqukayo anzima, kwaye iindidi eziphambili zesakhiwo ziyi-phenylpropanoids (i-phenylpropanoids elula, i-lignans kunye ne-coumarins) kunye ne-terpenoids (i-monoterpenes, i-sesquiterpenes, i-diterpenoids kunye ne-triterpenes). Amalungu angaguquguqukiyo ikakhulu ziialkaloids, aldehydes kunye neeasidi, iiquinones kunye neeketones, iisterols, amino acids, kunye neecarbohydrates. Iziphumo zophononongo lwe-ATR yokwakheka kweekhemikhali ziya kuba negalelo kuphuhliso lophando lomgangatho walo.
Ukuqulunqwa okuguquguqukayo
Abaphandi basebenzise iindlela zokuvavanya uhlalutyo ezifana ne-chromatography kunye ne-GC-MS ukuhlalutya iikhemikhali ze-ATR ezivela kwimvelaphi eyahlukeneyo, iibhetshi ezahlukeneyo, iindlela ezahlukeneyo zokutsalwa kunye namacandelo ahlukeneyo. Uphononongo lwangaphambili lubonise ukuba iikhemikhali eziphambili ze-ATR zaziyi-oyile eguquguqukayo, eyona nto ibalulekileyo yokuvavanya umgangatho we-ATR. I-α-Asarone kunye ne-β-asarone ibalwa kwi-95% ye-ATR yeoli eguquguqukayo kwaye ichongiwe njengamacandelo empawu (Umfanekiso woku-1) (Lam et al., 2016a). I-"Pharmacopoeia yeRiphabhlikhi yaBantu baseChina" (uHlelo lwe-2020) irekhoda ukuba umxholo we-oyile oguquguqukayo we-ATR akufanele ube ngaphantsi kwe-1.0% (mL/g). Okwangoku, iintlobo ezininzi ze-oyile eziguquguqukayo zifunyenwe kwi-ATR
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Ioyile ecocekileyo eneBranded enevumba elimnandi yekhandlela kunye nesepha yenza i-oyile ethengisayo idiffuser ebalulekileyo entsha kwizitshisi zengcongolo.
IPerilla yimifuno. Igqabi kunye nembewu zisetyenziselwa ukwenza iyeza.
I-Perilla isetyenziselwa ukunyanga isifo sombefu. Ikwasetyenziselwa isicaphucaphu, ukubethwa lilanga, ukubila, kunye nokunciphisa ukuqhawuka kwezihlunu.
Ekutyeni, i-perilla isetyenziswa njenge-flavoring.
Kwimveliso, ioli yembewu yeperilla isetyenziselwa urhwebo xa kuveliswa ivanishi, iidayi nee-inki.
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Ioyile ecocekileyo eneBranded enevumba elimnandi yekhandlela kunye nesepha yenza i-oyile ethengisayo idiffuser ebalulekileyo entsha kwizitshisi zengcongolo.
I-Angelica sisityalo. Iingcambu, imbewu kunye nesiqhamo zisetyenziselwa ukwenza iyeza.
I-Angelica isetyenziselwa i-heartburn, igesi yamathumbu (i-flatulence), ukulahlekelwa ngumdla (i-anorexia), isifo samathambo, iingxaki zokujikeleza kwegazi, "i-runny impumlo" (i-catarrh yokuphefumula), uvalo, isibetho, kunye neengxaki zokulala (ukulala).
Abanye abafazi basebenzisa i-angelica ukuqalisa ukuya exesheni. Maxa wambi oku kwenziwa ukuze kuphunyezwe.
I-Angelica ikwasetyenziselwa ukunyusa imveliso yomchamo, ukuphucula i-sex drive, ukuvuselela imveliso kunye nokukhupha i-phlegm, kunye nokubulala iintsholongwane.
Abanye abantu bafaka i-angelica ngqo eluswini ngenxa yeentlungu zemithambo-luvo (i-neuralgia), iintlungu zamalungu (i-rheumatism), kunye nokuphazamiseka kwesikhumba.
Ngokudityaniswa namanye amayeza, i-angelica ikwasetyenziselwa ukunyanga ukuphuma kwangaphambi kwexesha.
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I-100% ye-Herbal Essential Oli ye-Cyperus yokwenza isepha yokwenza i-Cyperus Rotundus Oli
I-Nutgrass yimifuno eyaziwayo esetyenziswa kuyo yonke imixube esebenzayo yokhathalelo lwesikhumba. Ngokwe-Ayurveda, isetyenzisiwe kwimixube eyahlukeneyo elungiselelwe ukukhanyisa amabala amnyama kunye njl.
Izibonelelo...
Kwakhona kufunyenwe kumayeza amaninzi e-Ayurvedic ukunyanga i-rashes, izifo zefungal kunye neemeko zesikhumba. Izicatshulwa zomgubo zeNutgrass ingcambu zinamandla kakhulu kwaye zityetyiswe nge-antioxidants, enceda ukucothisa ukuguga kolusu njengoko isebenza ukunciphisa imigca emihle kunye nemibimbi. Inceda ukulawula ukubunjwa ngokugqithisileyo kwe-pigment, i-melanin, eluswini. Ngaloo ndlela ibuyisela ukuqaqamba kolusu. I-Nutgrass iyaphola ngokwendalo, ipropathi yayo yokuchasa ukudumba inceda ukuthomalalisa ububomvu, ukugqabhuka, kunye nolusu oluvuthayo. Ibonakalise ukunyanga iimeko ezinzima zesikhumba. Ityebile kwiiasidi ezinamafutha, iivithamini kunye neeflavonoids eziluncedo kakhulu eluswini kunye neenwele. Ezi zakhiwo zongeza ukukhanya kwesikhumba, kwaye zomeleza iinwele ngokukhanya kunye nomthamo.
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Umgangatho ophezulu ococekileyo wendalo we-Notopterygium oyile esetyenziselwa ukhathalelo lwezeMpilo
Ngokumalunga nokugxotha umoya kunye nokuphelisa ukufuma, kukho ezininzi imifuno yaseTshayina efanelekayo. Ke ngoko, ukuthelekisa i-notopterygium kunye noontanga bayo abaneempawu zokuphilisa ezifanayo kuya kusinceda ukuba siqonde esi sityalo sonyango ngcono.
Zombini ingcambu ye-notopterygium kunye ne-Angelica Root (Du Huo) inokucoca umoya-manzi kwaye iphucule intlungu kunye nokuqina. Kodwa banamandla kunye nobuthathaka babo ngokulandelelana. Eyangaphambili inendalo eyomeleleyo kunye nencasa, eyenza ibe nefuthe elingcono le-antipyretic ngokubila kunye nokunyuka kwamandla. Ngenxa yeso sizathu, yimifuno efanelekileyo yezifo zomgogodla kunye neentlungu kumzimba ophezulu kunye nomva wentloko. Ngokuthelekisa, i-angelica ingcambu inamandla okuhla, enika amandla angcono okuphilisa kwi-rheumatism yomzimba ophantsi kunye neentlungu ezidibeneyo ezinyaweni, ezantsi, emlenzeni, nase-shin. Ngenxa yoko, zihlala zisetyenziswa ngababini ngamayeza kuba zihambelana kakhulu.
Zombini i-notopterygium kunyeUGui Zhi (Ramulus Cinnamomi)zikwazi ukukhupha umoya kunye nokususa ingqele. Kodwa lowo wangaphambili ukhetha ukufumisa umoya entloko, entanyeni, nasemva ngelixaUGu ZhiKungcono ukujongana nomoya-umanzi emagxeni, ezingalweni, kunye neminwe.
Bothe notopterygium kunyeIFang Feng (Radix Saposhnikoviae)zikhethekileyo ekukhupheni umoya. Kodwa eyokuqala inefuthe elinamandla kuneFang Feng.
Izenzo zanamhlanje ze-pharmacological ze-notopterygium ingcambu
1. Isitofu sayo sineempembelelo ze-analgesic kunye ne-antipyretic. Ukongezelela, inokuthintela kwi-fungus yesikhumba kunye ne-brucellosis;
2. Isahlulo saso esinyibilikayo sinovavanyo oluchasene ne-arrhythmic effect;
3. Ioli yayo eguquguqukayo nayo ine-anti-inflammatory, analgesic and antipyretic effects. Kwaye inokumelana ne-pituitrin-induced myocardial ischemia kunye nokwandisa ukuhamba kwegazi okunesondlo se-myocardial;
4. Ioyile yayo eguquguqukayo isanqanda ukulibaziseka kohlobo lwe-hypersensitivity kwiimpuku.Iiresiphi zesampula ze-notopterygium incisum kumayeza esintu
I-Zhong Guo Yao Dian (i-pharmacopoeia yaseTshayina) ikholelwa ukuba i-crid kwaye iyakrakra kwincasa kwaye ishushu kwindalo. Igubungela i-meridians yesinyi kunye nezintso. Imisebenzi ephambili kukukhupha umoya, ukukhupha ingqele, ukususa ubumanzi, kunye nokuphelisa iintlungu. Ukusetyenziswa kwe-notopterygium eyisiseko kunye nezibonakaliso zibandakanyaintloko ebuhlungukuhlobo olubandayo lomoyaokubandayo Okunye, i-rheumatism, kunye neentlungu ezibuhlungu emagxeni nasemqolo. Idosi ecetyiswayo isuka kwi-3 ukuya kwi-9 grams.
1. Qiang HuoFu ZiTang evela kuYi Xue Xin Wu (Izityhilelo zonyango). Idityaniswe neFu Zi (Iaconite),Gan Jiang(Ijinja eyomileyoIngcambu), kunye noZhiGan Cao(Ingcambu ye-Honey Fried Licorice) ukunyanga ubuchopho obuhlaselwe yintsholongwane ebandayo yangaphandle, iintlungu zobuchopho eziphuma emazinyweni, kumalungu abandayo, kunye nomoya opholileyo ophuma emlonyeni nasempumlweni.
2. Jiu Wei Qiang Huo Tang ukusukaCi ShiNan Zhi (Ulwazi olunzima). Yenziwe ngeFang Feng, Xi Xin (Herba Asari),Chuan Xiong(lovage ingcambu), njl njl. ukunyanga usulelo lwangaphandle olubanda emoyeni olukhatshwa kukufuma, ukubanda, umkhuhlane, ukubila, intloko ebuhlungu,intamo elukhuni, kunye neentlungu ezibukhali zamalungu emilenzeni.
3. I-Qiang Huo Sheng Shi Tang esuka ku-Nei Wai Shang Bian Huo Lun (Ukucacisa amathandabuzo malunga nokulimala kwiiMbangela zangaphakathi kunye nezangaphandle). Isetyenziswa kunye nengcambu ye-angelica,Gao Ben(Rhizoma Ligustici), iFang Feng, njl.njl. ukunyanga umoya omanzi wangaphandle, intloko ebuhlungu kunye ne-nape ebuhlungu, umqolo omuncu omuncu, kunye neentlungu ezidibeneyo zomzimba.
4. UJuan Bi Tang, owaziwa ngokuba yi-notopterygium kunyei-turmericindibaniselwano, ukusuka kwi-Bai Yi Xuan Fang (Imigqaliselo ekhethiweyo ngokuchanekileyo). Isebenza kunye noFang Feng, uJiang Huang (Curcuma Longa),Dang Gui(Dong Quai), njl njl ukuphelisa umoya-obandayo-umswakama we-arthralgia kumzimba ophezulu, intlungu edibeneyo yegxalaba kunye nemilenze.
5. Qiang Huo Gong Gao Tang evela eShen Shi Yao HanI-Ophthalmology). Idibana nengcambu ye-lovage,Bhayi Zhi(Angelica Dahurica), iRhizoma Ligustici, njl.
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I-oyile ye-lappa ye-Aucklandia ecocekileyo yekhandlela kunye nesepha yenza i-oyile ethengisayo idiffuser ebalulekileyo entsha kwizitshisi zeengcongolo
I-osteoarthritis (OA) sesinye sezifo zexesha elide ezingapheliyo ezichaphazela amathambo abantu abadala abangaphezu kweminyaka engama-65.1]. Ngokuqhelekileyo, izigulane ze-OA zifunyaniswa zine-cartilage eyonakeleyo, i-synovium evuthayo, kunye ne-chondrocytes ekhukhulayo, ebangela intlungu kunye nokukhathazeka ngokomzimba [2]. Intlungu yeArthritic ibangelwa kakhulu kukuwohloka kwe-cartilage kumalungu ngenxa yokudumba, kwaye xa i-cartilage yonakaliswe kakhulu amathambo anokubetha omnye komnye kubangele iintlungu ezinganyamezelekiyo kunye nobunzima bomzimba [3]. Ukubandakanyeka kwabalamli abavuthayo abaneempawu ezifana nentlungu, ukuvuvukala, kunye nokuqina komgudu kubhalwe kakuhle. Kwizigulane ze-OA, i-cytokines evuthayo, ebangela ukuguguleka kwe-cartilage kunye ne-subchondral bone ifumaneka kwi-synovial fluid [4]. Izikhalazo ezibini eziphambili ezithi izigulane ze-OA zibe nazo ngokubanzi ziintlungu kunye nokudumba kwe-synovial. Ke ngoko iinjongo eziphambili zolu nyango lwangoku lwe-OA kukuthoba iintlungu kunye nokudumba. [5]. Nangona unyango olukhoyo lwe-OA, kubandakanywa amachiza angeyo-steroidal kunye ne-steroidal, abonakalise ukusebenza kakuhle ekuthomalaliseni iintlungu kunye nokudumba, ukusetyenziswa kwexesha elide kwala machiza kuneziphumo ezibi zempilo ezinje nge-cardiovascular, gastro-intestinal, kunye nokungasebenzi kakuhle kwezintso [6]. Ke ngoko, iyeza elisebenzayo elineziphumo ebezingalindelekanga ezimbalwa kufuneka lenziwe kunyango lwe-osteoarthritis.Iimveliso zempilo zendalo ziya zithandwa kakhulu ukuze zikhuseleke kwaye zifumaneke lula [7]. Amayeza emveli aseKorea abonakalise ukusebenza ngempumelelo ngokuchasene nezifo ezininzi ezivuthayo, kubandakanya isifo samathambo [8]. Aucklandia lappa DC. iyaziwa ngeempawu zayo zonyango, ezifana nokuphucula ukujikeleza kwe-qi ukukhulula intlungu kunye nokuthomalalisa isisu, kwaye isetyenziswe ngokwesiko njenge-analgesic yendalo [9]. Iingxelo zangaphambili zibonisa ukuba i-A. lappa ine-anti-inflammatory [10,11], i-analgesic [12], umhlaza [13], kunye nokukhusela isisu [14] iziphumo. Imisebenzi eyahlukeneyo yebhayoloji ye-A. lappa ibangelwa zizixhobo zayo eziphambili ezisebenzayo: i-costunolide, i-dehydrocostus lactone, i-dihydrocostunolide, i-costuslactone, i-α-costol, i-saussurea lactone kunye ne-costuslactone [15]. Uphononongo lwangaphambili lubanga ukuba i-costunolide ibonise iipropati ezichasayo kwi-lipopolysaccharide (LPS), eyenza i-macrophages ngolawulo lwe-NF-kB kunye neprotheyini yokutshatyalaliswa kobushushu [16,17]. Nangona kunjalo, akukho phando luphande imisebenzi enokwenzeka ye-A. lappa yonyango lwe-OA. Uphando lwangoku luphande iziphumo zonyango lwe-A. lappa ngokuchasene ne-OA kusetyenziswa (i-monosodium-iodoacetate) i-MIA kunye neemodeli ze-acetic-induced rodent.I-Monosodium-iodoacetate (MIA) isetyenziswa ngokudumileyo ukuvelisa uninzi lweentlungu zokuziphatha kunye neempawu ze-pathophysiological ze-OA kwizilwanyana [.18,19,20]. Xa ijojowe kumalungu amadolo, i-MIA iphazamisa i-chondrocyte metabolism kwaye ibangele ukuvuvukala kunye neempawu ezivuthayo, ezifana ne-cartilage kunye ne-subchondral bone erosion, iimpawu zekhadinali ze-OA [18]. Ukuphendula okubhaliweyo okubangelwa i-acetic acid kuthathwa ngokubanzi njengokulinganisa intlungu ye-peripheral kwizilwanyana apho intlungu evuthayo inokulinganiswa ngokobungakanani [19]. I-mouse macrophage cell line, i-RAW264.7, isetyenziselwa ukufunda iimpendulo zeselula ekudumbeni. Emva kokusebenza kunye ne-LPS, i-RAW264 i-macrophages ivula iindlela ezivuthayo kwaye ikhuphe ama-intermediaries amaninzi avuthayo, njenge-TNF-α, i-COX-2, i-IL-1β, i-iNOS, kunye ne-IL-6 [20]. Olu pho nonongo luye lwavavanya i-anti-nociceptive kunye ne-anti-inflammatory effects ye-A. lappa ngokuchasene ne-OA kwimodeli yezilwanyana ze-MIA, imodeli yezilwanyana ze-acetic acid, kunye ne-LPS-activated RAW264.7 cells.2. Izinto kunye neendlela
2.1. Izinto zezityalo
Ingcambu eyomileyo ye-A. lappa DC. isetyenziswe kuvavanyo yathengwa kwi-Epulip Pharmaceutical Co., Ltd., (Seoul, Korea). Yachongwa nguProf. Donghun Lee, iSebe le-Herbal pharmacology, Col. of Korean Medicine, iYunivesithi yaseGachon, kunye nenombolo yomzekelo wevawutsha yafakwa njenge-18060301.2.2. Uhlalutyo lwe-HPLC lwe-A. lappa Extract
I-lappa ikhutshwe kusetyenziswa i-reflux apparatus (amanzi adibeneyo, i-3 h kwi-100 ° C). Isisombululo esikhutshwayo sahluzwa kwaye sancitshiswa kusetyenziswa i-evaporator yoxinzelelo oluphantsi. Isicatshulwa se-A. lappa sibe nesivuno se-44.69% emva kokumiswa komkhenkce ngaphantsi -80 °C. Uhlalutyo lweChromatographic ye-A. lappa lwenziwe nge-HPLC eqhagamshelwe kusetyenziswa i-1260 InfinityⅡ HPLC-system (Agilent, Pal Alto, CA, USA). Ukwahlula ikhromatic, ikholamu ye-EclipseXDB C18 (4.6 × 250 mm, 5 µm, Agilent) isetyenziswe kuma-35 °C. Ingqikithi ye-100 mg ye-specimen yahlanjululwa kwi-10 mL ye-50% ye-methanol kunye ne-sonicated ye-10 min. Iisampulu zahluzwa ngesihluzo sesirinji (Waters Corp., Milford, MA, USA) ye-0.45 μm. Ukubunjwa kwesigaba seselula kwakuyi-0.1% ye-phosphoric acid (A) kunye ne-acetonitrile (B) kwaye ikholamu yahlanjululwa ngolu hlobo lulandelayo: 0-60 min, 0%; 60–65 min, 100%; 65–67 min, 100%; I-67-72 min, i-0% ye-solvent B kunye nesantya sokuhamba kwe-1.0 mL / min. Amanzi amdaka ajongwe kwi-210 nm kusetyenziswa umthamo we-naliti ye-10 μL. Uhlalutyo lwenziwa kathathu.2.3. Izindlu zezilwanyana kunye noLawulo
Iigundane ze-Sprague-Dawley (SD) ezineminyaka eneeveki ze-5 kunye neempuku ze-ICR eziyindoda ezineminyaka eyi-6 iiveki zathengwa kwi-Samtako Bio Korea (Gyeonggi-do, Korea). Izilwanyana zazigcinwa kwigumbi kusetyenziswa ubushushu obungaguqukiyo (22 ± 2 °C) kunye nokufuma (55 ± 10%) kunye nomjikelo wokukhanya/omnyama we-12/12 h. Izilwanyana zaziqhelene nale meko ixesha elingaphezu kweveki ngaphambi kokuba kuqaliswe uvavanyo. Izilwanyana zazinobonelelo lwe-ad libitum yokutya kunye namanzi. Imithetho yokuziphatha yangoku yokunakekelwa kwezilwanyana kunye nokuphathwa kweYunivesithi yaseGachon (GIACUC-R2019003) ilandelwe ngokungqongqo kuzo zonke iinkqubo zovavanyo lwezilwanyana. Uphononongo lwenzelwe umphandi-mfameke kunye nolingo oluhambelanayo. Salandela indlela ye-euthanasia ngokwemigaqo ye-Animal Experimental Ethics Committee.2.4. Isitofu se-MIA kunye noNyango
Iimpuku zahlulwa ngokungenamkhethe zibe ngamaqela ama-4, angala, i-sham, ulawulo, i-indomethacin, kunye ne-A. lappa. Ukuba i-anesthetized kunye ne-2% ye-isofluorane umxube we-O2, iigundane zajojowe ngokusebenzisa i-50 μL ye-MIA (40 mg / m; Sigma-Aldrich, St. Louis, MO, USA) intra-articularly kwi-knee joints ukukhokelela kwi-OA yokuhlola. Unyango luqhutywe ngolu hlobo lungezantsi: ulawulo kunye namaqela e-sham agcinwe kuphela nge-AIN-93G yokutya okusisiseko. Kuphela, iqela le-indomethacin libonelelwe nge-indomethacin (3 mg / kg) efakwe kwi-AIN-93G yokutya kunye ne-A. lappa 300 mg / kg iqela labelwa kwi-AIN-93G yokutya eyongezwe nge-A. lappa (300 mg / kg). Unyango lwaqhutyekwa kwiintsuku ezingama-24 ukususela kwimini ye-OA yokufakwa kwizinga le-15-17 g nge-190-210 g ubunzima bomzimba imihla ngemihla.2.5. Ubungakanani bobunzima
Emva kokungeniswa kwe-OA, ukulinganiswa kwamandla okuthwala ubunzima bemilenze yangasemva kweerati zenziwa nge-incapacitance-MeterTester600 (IITC Life Science, Woodland Hills, CA, USA) njengoko kucwangcisiwe. Ukuhanjiswa kobunzima kumalungu angasemva kubalwa: ubunzima bokuthwala ubunzima (%) -
I-Angelica yaseShayina iDahurica Ingcambu ye-Oli ye-Massage
Ukusetyenziswa kweAngelica
Usetyenziso olongezelelekileyo kufuneka lube lolomntu ngamnye kwaye luvavanywe yingcali yezempilo, njengogqirha obhalisiweyo, usokhemesti, okanye umboneleli wezempilo. Akukho songezo senzelwe ukunyanga, ukunyanga, okanye ukuthintela izifo.
Ubungqina obunamandla besayensi obuxhasa ukusetyenziswa kwe-Angelica buyanqongophala. Ukuza kuthi ga ngoku, uninzi lophando kwiAngelica archangelicayenziwe kwiimodeli zezilwanyana okanye kwiindawo zaselabhoratri. Ngokubanzi, izilingo ezininzi zabantu ziyafuneka kwiinzuzo ezinokubakho ze-Angelica.
Oku kulandelayo kukujongwa kophando olukhoyo malunga nokusetyenziswa kwe-Angelica.
Nocturia
Nocturiayimeko echazwa njengemfuneko yokuvuka ebuthongweni kube kanye okanye nangaphezulu busuku ngabunye ukuze uchame. I-Angelica ifundelwe ukusetyenziswa kwayo ekudambiseni i-nocturia.
Kolunye uphononongo oluphindwe kabini olungaboniyo, abathathi-nxaxheba abane-nocturia ababelwe amadoda ekuzalweni kwabo babenziwa ngokungenamkhethe ukuba bafumaneindawo ye-placebo(into engasebenziyo) okanye imveliso eyenziwe kwiAngelica archangelicaigqabi iiveki ezisibhozo.4
Abathathi-nxaxheba bacelwa ukuba balandele kwiidayari xa besenzaumchamo. Abaphandi bavavanya iidayari zombini ngaphambi nangemva kwexesha lonyango. Ekupheleni kophononongo, abo bathatha i-Angelica babika ii-voids ezimbalwa zasebusuku (isidingo sokuvuka ezinzulwini zobusuku ukuchama) kunabo bathatha indawo ye-placebo, kodwa umahluko wawungabalulekanga.4
Ngelishwa, zimbalwa ezinye izifundo eziye zenziwa ukufumanisa ukuba i-Angelica inokuphucula kakhulu i-nocturia. Uphando olongezelelweyo luyafuneka kule ndawo.
Umhlaza
Ngelixa akukho ncediso okanye imifuno enokunyangaumhlaza, kukho umdla othile kwi-Angelica njengonyango olongezelelweyo.
Abaphandi baye bafunda iziphumo ze-Angelica ezinokuthi zibe nomhlaza kwilebhu. Kolunye uphando olunjalo, abaphandi bavavanyaAngelica archangelicakhupha kwiumhlaza webeleiiseli. Bafumanisa ukuba i-Angelica inokunceda ukubangela ukufa kweseli yomhlaza wamabele, ekhokelela abaphandi ukuba bagqibe kwelokuba imifuno inokuba nayoantitumorezinokubakho.5
Uphononongo oludala kakhulu olwenziwe kwiigundane lufumene iziphumo ezifanayo.6 Nangona kunjalo, ezi ziphumo azizange ziphindwe kabini kwizilingo zabantu. Ngaphandle kwezilingo zabantu, akukho bungqina bokuba i-Angelica inokunceda ukubulala iiseli zomhlaza womntu.
Ukuxhalaba
I-Angelica isetyenziswe kumayeza esintu njengonyangoixhala. Noko ke, ubungqina benzululwazi obuxhasa eli bango bunqabile.
Njengolunye usetyenziso lwe-Angelica, uphando malunga nokusetyenziswa kwayo kwixhala luye lwenziwa ikakhulu kwiisetingi zaselebhu okanye kwiimodeli zezilwanyana.
Kolunye uphononongo, izicatshulwa ze-Angelica zanikwa iimpuku ngaphambi kokuba zenzeuxinzeleloiimvavanyo. Ngokutsho kwabaphandi, iigundane zenze ngcono emva kokufumana i-Angelica, okwenza kube yinto yonyango yokukhathazeka.7
Izilingo zabantu kunye nophando olunamandla ngakumbi luyafuneka ukuze kubonwe indima enokubakho ka-Angelica ekunyangeni ixhala.
Iimpawu zeAntimicrobial
U-Angelica kuthiwa uneempawu ze-antimicrobial, kodwa uphando lwabantu oluyilwe kakuhle aluzange lwenziwe ukungqina eli bango.
Ngokutsho kwabanye abaphandi, i-Angelica ibonisa umsebenzi we-antimicrobial ngokuchasene ne:2
- Clostridium difficile (C. yahluka)
- I-Clostridium perfringens
- Enterococcus faecalis
- Eubacterium limosum
- I-Peptostreptococcus anaerobius
- Candida albicans
Nangona kunjalo, umxholo omncinci unikiwe malunga nendlela i-Angelica enokuthi ithintele ngayo ezi kunye nezinye iibhaktheriya kunye nomngundo.
Okunye Ukusetyenziswa
Kumayeza esintu,Angelica archangelicaisetyenziselwa ukunyanga izigulo ezongezelelweyo, kuquka:1
Ubungqina bobunzululwazi obusemgangathweni obuxhasa olu setyenziso bulinganiselwe. Qinisekisa ukuthetha nomboneleli wezempilo ngaphambi kokusebenzisa i-Angelica kwezi kunye nezinye iimeko zempilo.
Ziziphi iimpembelelo ze-Angelica?
Njengayo nayiphi na imifuno okanye isongezelelo, i-Angelica inokubangela iziphumo ebezingalindelekanga. Nangona kunjalo, ngenxa yokunqongophala kwezilingo zabantu, kuye kwakho iingxelo ezimbalwa zeziphumo ebezingalindelekanga ze-Angelica.
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Pure zendalo eziphilayo magnolia kubalulekile oyile flos magnoliae ioli ioli yesiqholo
IMagnoliae Flos yinto eqhelekileyo esetyenziswa ngamayeza esintu eAsia. Isetyenziselwa ukunyanga i-sinusitis, ukuxinana kweempumlo, kunye nolusu lwe-hypersensitive. Ngenxa yokuba iMagonlia Flos yayichazwa njengesixhobo esinevumba elimnandi kwimibhalo yakudala yaseTshayina, saqikelela ukuba ioyile yayo eyimfuneko inokusetyenziselwa ukunyanga izifo zokhuselo lomzimba. Iiseli ze-Dendritic (i-DCs), ezithathwa njengeyona njongo iphambili ye-immunomodulators ukulawula iimpendulo ze-immune, zidlala indima ebalulekileyo kwi-adaptive immune response. Kulo cwaningo, i-Magnoliae Flos ioli ebalulekileyo (i-MFEO) iyancipha ukuveliswa kwe-cytokines TNF-α, IL-6, kunye ne-IL-12p70 kwi-lipopolysaccharide (LPS) -i-DCs evuselelwe. Ikwacinezela iziphawuli ezingaphezulu kwe-MHC II, i-CD80, kunye ne-CD86 kwii-DCs ezivuselelweyo ze-LPS. Iimodeli zezilwanyana zibonise ukuba i-2,4-Dinitro-1-fluorobenzene (DNFB) ibangela ukuba impendulo ye-hypersensitivity yoqhagamshelwano yayithintelwe emva konyango kunye ne-MFEO. Ukongezelela, i-MFEO ivimbele ukungena kweeseli ze-T ezindlebeni ze-DNFB-induced mice. Ukuphonononga iikhompawundi zayo ze-bioactive, amacandelo e-MFEO ahlalutywa ngokusebenzisa i-chromatography yegesi (GC) kunye ne-GC-mass spectrometry. Iziphumo zibonise ukuba iikhompawundi ezinkulu kwi-MFEO ziyi-camphor kunye ne-1,8-cineole. Uvavanyo olongezelelweyo lwe-DC luqinisekisile ukuba ezi khompawundi zicinezele kakhulu imveliso ye-cytokine kwii-DCs ezenziwe nge-LPS. Ngoko ke, sibonise ukuba i-MFEO ibonisa i-immunosuppressive effect zombini kwi-vivo kunye ne-vitro, kunye ne-camphor kunye ne-1,8-cineole ingaba ngamacandelo amakhulu ajongene nekhono layo lokukhusela. Iziphumo zibonisa ukuba i-MFEO inamandla okuphuhliswa njenge-immunosuppressant entsha yezifo ezigqithisileyo.
